You can't live without NAD+.

The bad news: NAD+ levels are destroyed by aging, inflammation, diet, stress, and sickness. This leads to weakness, frailty, and even faster aging.


The good news: You can help restore your NAD+ levels with exercise, nutrition, and targeted supplement formulas.

NAD+ precursor response is personal.

The enzymes that rebuild your NAD+ stores vary by person and tissue, so the same supplement doesn’t always produce the same effect.


Supporting multiple pathways with NMN, NR, and Trigonelline helps you get reliable, steady NAD+ support without guesswork.

NAD+ boosters like NMN and NR are only the beginning.

After years of analyzing the research, we've aligned with a systems-level approach to address four main pathways to support healthy NAD+ levels throughout the entire body. This systems-level approach is described elegantly by Nichola Conlon and Dianne Ford in a recent study on NAD+ restoration.
Every Renue By Science formula helps you maximize NAD+ through one of these pathways.

Boost

Protect

Optimize

Regenerate

Why all four pathways matter.

Each pathway addresses a different bottleneck in NAD+ metabolism, and they work synergistically:

  • BOOST provides NAD+ precursors through multiple biosynthetic routes: salvage, Preiss-Handler, and NR kinase pathways. This increases substrate availability for NAD+ production.

  • PROTECT inhibits CD38 and reduces inflammation-drivenNAD+consumption. CD38 activity can consume 100x moreNAD+than other enzymes, so blocking it preserves yourNAD+pool.

  • OPTIMIZE improves mitochondrial efficiency through SIRT1 activation and AMPK signaling. More efficient mitochondria require less NAD+ to produce the same amount of ATP.

  • REGENERATE activates autophagy and cellular cleanup during sleep, reducing the accumulated damage that creates NAD+ demand for repairs.

    • BOOST provides NAD+ precursors through multiple biosynthetic routes: salvage, Preiss-Handler, and NR kinase pathways. This increases substrate availability for NAD+ production.

    • PROTECT inhibits CD38 and reduces inflammation-drivenNAD+consumption. CD38 activity can consume 100x moreNAD+than other enzymes, so blocking it preserves yourNAD+pool.

      • OPTIMIZE improves mitochondrial efficiency through SIRT1 activation and AMPK signaling. More efficient mitochondria require less NAD+ to produce the same amount of ATP.

      • REGENERATE activates autophagy and cellular cleanup during sleep, reducing the accumulated damage that creates NAD+ demand for repairs.

        When combined, these pathways create a positive feedback loop:

        Multiple precursors prevent pathway saturation.

        CD38 inhibition preserves what you produce.

        Efficient mitochondria reduce NAD+ consumption.

        Overnight cleanup minimizes repair demands.

        The result:NAD+levels rise and stabilize rather than experiencing the typical single-supplement plateau. Research shows multi-pathway interventions achieve better outcomes than single precursor supplementation alone.

        Making It Real.

        Understanding the four pathways changes how you think about energy and aging. You now see why that afternoon crash happens, why recovery takes longer than it used to, and why some supplements work initially then fade.

        More importantly, you understand there's a systematic way forward.

        Some people start with just one pathway, usually BOOST for quick energy improvements or PROTECT if they're already taking supplements that seem less effective than before. Others prefer addressing multiple pathways together for synergistic benefits.

        What most people find: Starting somewhere, even imperfectly, teaches you what your body responds to. The first positive change usually happens within the first two weeks. That initial improvement often clarifies what to adjust next.

        The research provides the map. Your experience becomes the compass.

        The liposome advantage: understanding advanced delivery technology.

        Liposomal Delivery Protects Ingredients

        What Are Liposomes and Why Do They Matter?

        Liposomes are microscopic spheres made of phospholipids: the same material that forms your cell membranes. When these dry, powdered phospholipids are mixed with water, they spontaneously organize into protective bubbles that can encapsulate nutrients and deliver them more effectively to your cells.
        Liposomes solve the bioavailability problem that many ingredients have. Many beneficial nutrients, especially polyphenols and other plant extracts, have absorption rates of less than 10%, and sometimes as low as 1% for molecules like resveratrol.¹ By protecting nutrients through digestion and facilitating their absorption, liposomal delivery can dramatically improve how much of each ingredient actually reaches your bloodstream and cells.

        •  

          The core benefits: what human studies show.

          ➡ Bioavailability benefits with real numbers.
          Clinical trials demonstrate the difference liposomal delivery makes. A 2024 randomized controlled trial showed liposomal vitamin C produced higher plasma levels and maintained them longer compared to standard ascorbic acid.² For glutathione, both liposomal and non-liposomal oral forms have successfully raised glutathione status in humans, with liposomal forms outperforming the standard versions.

          ➡ Protection and stability.
          Liposomal encapsulation shields active ingredients from stomach acid (pH < 2), digestive enzymes, and oxidation - all factors that normally destroy sensitive nutrients before absorption. The phospholipid bilayer maintains compound integrity during storage and through the digestive system.

          ➡ Higher concentration per dose.
          Unlike simple capsules or tablets, liposomes can carry both water-soluble and fat-soluble nutrients together, which lets us create more complex formulas to suit various needs. This dual-loading capacity means more nutrient per particle reaches your system.

        How liposomal technology works.

        • THE PROTECTION PHASE

          When you swallow a supplement formulated with liposomes, the phospholipid bilayer acts as a molecular shield to protect the nutrients through digestion. Advanced formulations use specialized phospholipids to resist breakdown from bile salts and maintain stability through your entire digestive tract.







        • CROSSING THE INTESTINAL BARRIER

          Something interesting happens when liposomes reach your intestines. The small liposome size, ideally 100-200 nanometers, allows them to navigate through intestinal mucus and trigger cellular uptake. The primary absorption route occurs through specialized M cells and enterocytes in your Peyer's patches via endocytosis, essentially being swallowed whole by intestinal cells.

          Even if some liposomes break down, the phospholipids help solubilize nutrients in your intestinal environment, creating additional absorption opportunities.

        • CELLULAR INTEGRATION

          After absorption, the phospholipid structure continues working. These lipids integrate with your cellular membranes more readily than free compounds, potentially improving delivery to target tissues. Plus, the phospholipids themselves, particularly phosphatidylcholine, provide nutritional benefits for cell membrane health, liver function, and cognitive performance.

          Liposomal delivery for NAD+ precursors: NMN and NR.

          THE CHALLENGE WITH NAD+ PRECURSORS.

          NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) face unique absorption challenges that make them ideal candidates for liposomal delivery. Research has identified that NMN is absorbed through the small intestine, including transporters like SLC12A8, with the CD73 enzyme facilitating uptake, but this process is pH-dependent and can be compromised by stomach acid. Additionally, both compounds are rapidly metabolized: NMN can be broken down to nicotinamide by CD38 and other enzymes before reaching target tissues.

          Studies show that while oral NMN does raise NAD+ levels, the conversion efficiency varies significantly between individuals, likely due to differences in digestive conditions and enzyme activity.  NR faces similar challenges, with intestinal and hepatic metabolism converting much of it to nicotinamide before it can raise NAD+ in target tissues.

          The bottom line.

          Liposomal technology offers documented advantages for nutrients with absorption challenges. The phospholipid bilayer provides multiple benefits: protection from digestive breakdown, absorption through intestinal barriers, larger nutrient payloads, and potentially more consistent blood levels.

          Not every supplement needs liposomal delivery, but for compounds with known bioavailability problems, particularly expensive nutrients where you want maximum value, the technology can make the difference between an expensive placebo and an effective supplement. The science is mature, the benefits are measurable, and when properly formulated, liposomes deliver on their promise of better bioavailability.

          Liposomal delivery addresses each of these challenges systematically.

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